2013-2017,
Over the last 70 years many causes of traumatic brain injury (TBI) due to impact have been proposed. These include acceleration-deceleration of the head, intracranial pressure changes, stress waves, relative motion of the brain with respect to the skull, and cavitation. However, these causes utterly fail to describe quantitatively the main cause of injury, which is excessive tissue deformation. In our opinion, it is apparent that there still exists a debate on the main causes of TBI, and injury thresholds still has to be quantitatively understood.
Our long-term research goal is to establish a correlation between quantifiable mechanical parameters, such as deformation, strain and strain rate response, and underlying biological mechanisms responsible for tissue damage and impairment observed after impact events, and thereby improve prevention, diagnosis and treatment of TBI.
- We have developed an experimental setup, HAMr, in which brain cells have been impacted under highly controlled settings. Then, both mechanical and biological response have been recorded.
- We have also developed a pendulum impactor setup in which more realistic skull geometries can be studied carefully during and after a dynamic impact.
In this project we also use ultra high-speed imaging techniques to capture the dynamic response of the sample.